Amphipath-induced nanoscale changes in outer hair cell plasma membrane curvature.

  title={Amphipath-induced nanoscale changes in outer hair cell plasma membrane curvature.},
  author={Jennifer N Greeson and Robert M. Raphael},
  journal={Biophysical journal},
  volume={96 2},
Outer hair cell (OHC) electromotility enables frequency selectivity and sensitivity in mammalian audition. Electromotility is generated by the transmembrane protein prestin and is sensitive to amphipathic compounds including salicylate, chlorpromazine (CPZ), and trinitrophenol (TNP). Although these compounds induce observable membrane curvature changes in erythrocytes, their effects on OHC membrane curvature are unknown. In this work, fluorescence polarization microscopy was applied to… CONTINUE READING
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