Amphibian ryanodine receptor isoforms are related to those of mammalian skeletal or cardiac muscle.

@article{Lai1992AmphibianRR,
  title={Amphibian ryanodine receptor isoforms are related to those of mammalian skeletal or cardiac muscle.},
  author={F Anthony Lai and Q. Y. Liu and Le Xu and Anita El-Hashem and Neal R. Kramarcy and Robert Sealock and Gerhard Meissner},
  journal={The American journal of physiology},
  year={1992},
  volume={263 2 Pt 1},
  pages={C365-72}
}
The ryanodine receptor (RyR)-Ca2+ release channels of frog skeletal muscle have been purified as 30S protein complexes comprised of two high molecular weight polypeptides. The upper and lower bands of the frog doublet comigrated on sodium dodecyl sulfate polyacylamide gels with the mammalian skeletal and cardiac RyR polypeptides, respectively. Immunoblot analysis showed that a polyclonal antiserum to the rat skeletal RyR preferentially cross-reacted with the upper band, whereas monoclonal… CONTINUE READING