Amphetamine-sensitized animals show a sensorimotor gating and neurochemical abnormality similar to that of schizophrenia.

@article{Tenn2003AmphetaminesensitizedAS,
  title={Amphetamine-sensitized animals show a sensorimotor gating and neurochemical abnormality similar to that of schizophrenia.},
  author={Catherine C. Tenn and Paul N. Fletcher and Shitij Kapur},
  journal={Schizophrenia research},
  year={2003},
  volume={64 2-3},
  pages={103-14}
}
The aim of these studies was to examine whether amphetamine-induced sensitization in rats could be used as an animal model to study the basis of certain abnormalities seen in schizophrenia. Specifically, these experiments examined whether rats subjected to a sensitizing regimen of amphetamine would show the sensorimotor gating and greater amphetamine-induced displacement of radio-raclopride binding deficit that is observed in schizophrenia. In the first experiment, animals were divided into two… CONTINUE READING
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