Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms

@article{Moratalla2017AmphetaminerelatedDN,
  title={Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms},
  author={Rosario Moratalla and Amit Khairnar and Nicola Simola and Noelia Granado and Micaela Morelli},
  journal={Progress in Neurobiology},
  year={2017},
  volume={155},
  pages={149-170}
}
  • Rosario Moratalla, Amit Khairnar, +2 authors Micaela Morelli
  • Published in Progress in Neurobiology 2017
  • Biology, Medicine
  • HIGHLIGHTSMDMA damages serotonergic system in primates and rats and dopaminergic system in mice.METH damages the dopaminergic system in all animal species including humans.The nigrostriatal system is more vulnerable than the mesolimbic system.Within the striatum the striosomes are more vulnerable than the matrix.METH kills dopamine neurons as demonstrated by silver‐staining in rodents.METH reduces DAT binding sites and motor skills in human addicts. ABSTRACT Amphetamine‐related drugs, such as 3… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 53 CITATIONS, ESTIMATED 48% COVERAGE

    5 Manifestations of Methamphetamine Poisoning

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats

    VIEW 10 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age

    VIEW 7 EXCERPTS
    CITES BACKGROUND

    RIP3/MLKL-mediated neuronal necroptosis induced by methamphetamine at 39°C

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Cell Clearing Systems Bridging Neuro-Immunity and Synaptic Plasticity

    FILTER CITATIONS BY YEAR

    2016
    2020

    CITATION STATISTICS

    • 4 Highly Influenced Citations

    • Averaged 14 Citations per year from 2017 through 2019

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 351 REFERENCES

    MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA-pretreated mice.

    VIEW 7 EXCERPTS

    Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview

    VIEW 7 EXCERPTS
    HIGHLY INFLUENTIAL