Amphetamine regulates gene expression in rat striatum via transcription factor CREB.

  title={Amphetamine regulates gene expression in rat striatum via transcription factor CREB.},
  author={Christine Konradi and Rebecca L Cole and Stephan Heckers and Steven E Hyman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={14 9},
Amphetamine is a psychostimulant drug of abuse that can produce long-lived changes in behavior including sensitization and dependence. The neural substrates of these drug effects remain unknown, but based on their prolonged time course, we hypothesize that they involve drug-induced alterations in gene expression. It has recently been demonstrated that amphetamine regulates the expression of several genes, including c-fos, via dopamine D1 receptors in rat striatum. Here we report that… CONTINUE READING
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