Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2'-methyl-MPTP.

@article{Szirki1994AmphetaminemetabolitesOD,
  title={Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2'-methyl-MPTP.},
  author={I Szir{\'a}ki and V S Kardos and M Patthy and M{\'a}rta P{\'a}tfalusi and J{\'o}zsef Ga{\'a}l and Magda Solti and Erno Koll{\'a}r and Josef Singer},
  journal={Journal of neural transmission. Supplementum},
  year={1994},
  volume={41},
  pages={207-19}
}
The ability of 1-deprenyl to protect against the parkinsonian effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been attributed to the inhibition of conversion of MPTP to MPP+ (1-methyl-4-phenylpyridinium) catalyzed by MAO-B. We report here that deprenyl-treatment in mice has an additional neuroprotective element associated with the rapid metabolization of 1-deprenyl to 1-methamphetamine and 1-amphetamine. 1-Methamphetamine and 1-amphetamine inhibit MPP(+)-uptake into striatal… CONTINUE READING