Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway.

@article{Krasnova2005AmphetamineIA,
  title={Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway.},
  author={Irina N. Krasnova and Bruce Ladenheim and Jean Lud Cadet},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 7},
  pages={
          851-3
        }
}
Amphetamine (AMPH) is a psychostimulant whose chronic abuse may cause impairments in attention and memory in humans. These cognitive deficits might be related to neurotoxic effects of the drug. One such toxic effect is the well-described destruction of striatal dopaminergic terminals in mammals. In the present study, we investigated the possibility that AMPH might also cause neuronal apoptosis in the rodent striatum. Administration of a dose of the drug (10 mg/kg, 4 times, every 2 h) that is… CONTINUE READING
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