Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria

@article{Drevets2001AmphetamineinducedDR,
  title={Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria},
  author={Wayne C. Drevets and C H Gautier and Julie C. Price and David J. Kupfer and Paul Kinahan and Anthony A. Grace and Joseph L. Price and Chester A. Mathis},
  journal={Biological Psychiatry},
  year={2001},
  volume={49},
  pages={81-96}
}

Figures and Tables from this paper

Amphetamine potency varies with dopamine uptake rate across striatal subregions
TLDR
Using fast scan cyclic voltammetry in mouse brain slices, amphetamine effects at the DAT and on release decreased across regions from dorsal to ventral, and both measures of potency were highly correlated with dopamine uptake rates.
Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum
  • D. Martínez, M. Slifstein, M. Laruelle
  • Biology, Psychology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
TLDR
Results show significant differences in the dopamine response to amphetamine between the functional subdivisions of the human striatum, which may be related to the asymmetrical feed-forward influences mediating the integration of limbic, cognitive, and sensorimotor striatal function via dopamine cell territories in the ventral midbrain.
Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine
TLDR
Evidence is provided of interrelationships between glucocorticoid levels, subjective responses to IV AMPH, and brain DA release in humans, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans.
Alcohol promotes dopamine release in the human nucleus accumbens
TLDR
The first report that, in humans, alcohol promotes dopamine release in the brain, with a preferential effect in the ventral striatum, is reported, supporting the hypothesis that mesolimbic dopamine activation is a common property of abused substances, possibly mediating their reinforcing effects.
Amphetamine-Induced Displacement of [18F] Fallypride in Striatum and Extrastriatal Regions in Humans
TLDR
It is demonstrated that [18F]fallypride PET studies using oral D-AMPH (0.43 mg/kg) can be used to study D- AMPH-induced DA release in the striatal and extrastriatal regions in humans, and their relationship with cognition and sensation-seeking behavior.
Heightened Dopaminergic Response to Amphetamine at the D3 Dopamine Receptor in Methamphetamine Users
TLDR
Evidence is provided that dopamine transmission in extrastriatal ‘D3-areas’ is not blunted but rather increased in MA users, which suggests that greater dopaminergic transmission at the D3 dopamine receptor may contribute to motivation to use drugs and argues in favor of D3 antagonism as a possible therapeutic tool to reduce craving and relapse in MA addiction.
Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.
TLDR
REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate, which could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants.
Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study.
BACKGROUND A dopaminergic response to alcohol in humans has not been demonstrated consistently with positron emission tomography (PET). We hypothesized that the effect of alcohol on striatal dopamine
...
...

References

SHOWING 1-10 OF 145 REFERENCES
PET Measures of Amphetamine-Induced Dopamine Release in Ventral versus Dorsal Striatum
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
  • G. Di Chiara, A. Imperato
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1988
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.
  • A. Breier, T. Su, D. Pickar
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
In the clinical study, patients with schizophrenia compared with healthy volunteers had significantly greater amphetamine-related reductions in [11C]raclopride specific binding, providing direct evidence for the hypothesis of elevated Amphetamine-induced synaptic dopamine concentrations in schizophrenia.
Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis
  • R. Kuczenski, D. Segal
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1989
TLDR
The results suggest that the behavioral response to AMPH may be influenced by the interaction between levels of DA and 5-HT release, as well as by the state of their respective receptors.
Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.
TLDR
It is shown that stimulant-induced high, a mood descriptor that reflects reinforcing effects of drugs in humans, is associated with increases in brain dopamine, and also that there is a quantitative relationship between levels of D(2) receptor occupancy by dopamine and the intensity of the high.
Does amphetamine preferentially increase the extracellular concentration of dopamine in the mesolimbic system of freely moving rats?
  • T. Robinson, D. Camp
  • Biology
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • 1990
TLDR
The hypothesis that drugs of abuse preferentially increase the extracellular concentration of dopamine (DA) in mesolimbic structures is not supported, although other ways in which amphetamine may selectively influence meslimbic DA activity are discussed.
Microdialysis and SPECT measurements of amphetamine‐induced dopamine release in nonhuman primates
TLDR
The measure of amphetamine‐induced dopamine release with SPECT in nonhuman primates is validated and the use of this SPECT paradigm as a noninvasive measurement of intrasynaptic dopamine release in the living brain is validated.
...
...