Amphetamine and the reward system: Evidence for tolerance and post-drug depression

@article{Leith2004AmphetamineAT,
  title={Amphetamine and the reward system: Evidence for tolerance and post-drug depression},
  author={N. Leith and R. Barrett},
  journal={Psychopharmacologia},
  year={2004},
  volume={46},
  pages={19-25}
}
Existing reports of tolerance to the behavioral effects of d-amphetamine are most parsimoniously interpreted as reflecting behavioral adaptation to the disruptive effects of the drug rather than physiological tolerance. The present study shows that physiological tolerance does develop to the facilitation of self-stimulation behavior which the drug produces. Rats were trained to bar-press for electrical stimulation of the medial forebrain bundle and tested for facilitation of responding… Expand
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