Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms

@article{Achterberg2013AmphetamineAC,
  title={Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms},
  author={E. J. Marijke Achterberg and Viviana Trezza and Stephen M Siviy and Laurens Schrama and Anton N. M. Schoffelmeer and Louk J.M.J. Vanderschuren},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={1503-1515}
}
RationaleSocial play behavior is a characteristic form of social behavior displayed by juvenile and adolescent mammals. This social play behavior is highly rewarding and of major importance for social and cognitive development. Social play is known to be modulated by neurotransmitter systems involved in reward and motivation. Interestingly, psychostimulant drugs, such as amphetamine and cocaine, profoundly suppress social play, but the neural mechanisms underlying these effects remain to be… 
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Induction and Blockade of Adolescent Cocaine-Induced Habits
TLDR
It is suggested that adolescent cocaine exposure confers a bias toward habit-based behavior in adulthood via long-term cellular structural modifications in the oPFC, and treatments aimed at mitigating the durable consequences of early-life cocaine use may benefit from targeting cytoskeletal regulatory systems.
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