Amphetamine and LSD as discriminative stimuli: Alterations following neonatal monoamine reductions

@article{Minnema1984AmphetamineAL,
  title={Amphetamine and LSD as discriminative stimuli: Alterations following neonatal monoamine reductions},
  author={D. Minnema and J. Rosecrans},
  journal={Pharmacology Biochemistry and Behavior},
  year={1984},
  volume={20},
  pages={95-101}
}
  • D. Minnema, J. Rosecrans
  • Published 1984
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
  • Male adult Sprague-Dawley rats (70 days of age), neonatally depleted of either 5-hydroxytryptamine (5HT) via 5,7-dihydroxytryptamine (5,7-DHT; ICS) + desmethylimipramine (DMI; IP) at 3 days of age or dopamine (DA) via 6-hydroxydopamine (6-OHDA; ICS) + DMI at 14 days of age, were trained to discriminate either d-LSD-tartrate (80 micrograms/kg; IP) or d-amphetamine (d-AMPH) sulfate (0.90 mg/kg; IP) from saline utilizing a two lever drug discrimination paradigm. A neurochemical analysis at the… CONTINUE READING
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