Amphetamine‐type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

  title={Amphetamine‐type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin},
  author={R. Rothman and M. Baumann and C. Dersch and D. Romero and K. Rice and F. Carroll and J. Partilla},
  • R. Rothman, M. Baumann, +4 authors J. Partilla
  • Published 2001
  • Psychology, Medicine
  • Synapse
  • A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine. The role DA plays in mediating amphetamine‐type subjective effects of stimulants in humans remains to be established. Both amphetamine and cocaine increase norepinephrine (NE) via stimulation of release and inhibition of reuptake, respectively. If increases in NE mediate amphetamine‐type… CONTINUE READING
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