Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro

@article{Sinan2006AmphenicolAM,
  title={Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro},
  author={S. Oznur Sinan and Feray Kockar and Nahit Gençer and Hatice Kalkan Yildirim and Oktay Arslan},
  journal={Biochemistry (Moscow)},
  year={2006},
  volume={71},
  pages={46-50}
}
Human serum paraoxonase (hPON1) was separately purified by ammonium sulfate precipitation and hydrophobic interaction chromatography. The in vitro effects of commonly used antibiotics, namely clarithromycin and chloramphenicol, on purified human serum paraoxonase enzyme activity (serum hPON1) and human hepatoma (HepG2) cell paraoxonase enzyme activity (liver hPON1) were determined. Serum hPON1 and liver hPON1 were determined using paraoxon as a substrate and IC50 values of these drugs… CONTINUE READING

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