Amperometric aptasensor for thrombin detection using enzyme-mediated direct electrochemistry and DNA-based signal amplification strategy.

@article{Bai2013AmperometricAF,
  title={Amperometric aptasensor for thrombin detection using enzyme-mediated direct electrochemistry and DNA-based signal amplification strategy.},
  author={Lijuan Bai and Y. I. Chai and Ruo Yuan and Yali Yuan and Shunbi Xie and Liping Jiang},
  journal={Biosensors & bioelectronics},
  year={2013},
  volume={50},
  pages={325-30}
}
In this work, a new electrochemical aptasensor based on direct electron transfer and electrocatalysis of horseradish peroxidase (HRP) using exonuclease-catalyzed target recycling and hybridization chain reaction (HCR) for signal amplification was developed for highly sensitive detection of thrombin. The electrochemical signal was originated from HRP without… CONTINUE READING