Amoxycillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis

@article{Dattwyler1990AmoxycillinPP,
  title={Amoxycillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis},
  author={Raymond J. Dattwyler and David J. Volkman and S. M. Conaty and S. P. Platkin and Benjamin J. Luft},
  journal={The Lancet},
  year={1990},
  volume={336},
  pages={1404-1406}
}

Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease.

TLDR
In patients with acute disseminated Lyme disease but without meningitis, oral doxycycline and parenterally administered ceftriaxone were equally effective in preventing the late manifestations of disease.

Comparison of Azithromycin and Doxycycline in the Treatment of Erythema migrans

TLDR
Azithromycin (a total dose of 3 g) is equally effective as standard doxycycline treatment for erythema migrans in adult patients in a randomized, multicenter, open clinical trial.

Azithromycin versus penicillin V for the treatment of early lyme borreliosis

TLDR
Azithromycin appears to be as effective as penicillin V for the treatment of early Lyme borreliosis and it seems to clear the erythema migrans more promptly.

Oral doxycycline versus intravenous ceftriaxone for treatment of multiple erythema migrans: an open-label alternate-treatment observational trial

TLDR
The 14 day oral doxycycline was not inferior to the 14’day intravenous ceftriaxone in treatment of adult European patients with early disseminated Lyme borreliosis manifested as multiple EM, and the frequency of non-specific symptoms in patients was similar to that in controls.

Treatment of erythema migrans with doxycycline for 10 days versus 15 days.

TLDR
The 10-day regimen of oral doxycycline was not inferior to the 15- day regimen among adult European patients with solitary erythema migrans and the frequency of nonspecific symptoms after treatment was similar to that among control subjects.

Erythema migrans: Three Weeks treatment for prevention of late Lyme borreliosis

TLDR
A 3-week course of treatment with penicillin or minocycline is equally effective in treating patients with erythema migrans and preventing late symptoms of Lyme borreliosis.

Comparison of intravenous penicillin G and oral doxycycline for treatment of Lyme neuroborreliosis

TLDR
Oral doxycycline is an adequate and cost-effective alternative to IV penicillin for the treatment of Lyme neuroborreliosis and there were no significant differences between the two treatment groups in patient scoring, CSF analysis, or serologic and clinical follow-up during 1 year.

Azithromycin Compared with Amoxicillin in the Treatment of Erythema Migrans: A Double-Blind, Randomized, Controlled Trial

TLDR
A large, multicenter, double-blind, randomized trial on the treatment of Lyme disease with azithromycin, an azalide (a new subclass of macrolide antibiotics), chosen as the comparative agent to circumvent the problems associated with sun-related hypersensitivity reactions.
...

References

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Treatment of Erythema Chronicum Migrans of Lyme Disease

  • B. W. Berger
  • Medicine
    Annals of the New York Academy of Sciences
  • 1988
TLDR
Although it is too early to judge the efficacy of treatment in these patients, increases in the incidence of Herxheimer reactions and drug eruptions were observed and strict compliance with treatment protocols and the possibility of reactions to medications should be thoroughly discussed with patients.

New Chemotherapeutic Approaches in the Treatment of Lyme Borreliosis a

1. It was demonstrated that while B. burgdorferi may be sensitive to relatively small concentrations of penicillin and ceftriaxone, the organism is killed slowly. This implies that, as in syphilis,

Treatment of the early manifestations of Lyme disease.

TLDR
For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin; with all three antibiotic agents nearly half of the patients had minor late symptoms such as headache, musculoskeletal pain, and lethargy.

Failure of tetracycline therapy in early Lyme disease.

TLDR
The clinical courses of 5 patients with Lyme disease who developed significant late complications, despite receiving tetracycline early in the course of their illness are described, suggesting that the use of tetrACYcline at a dosage of 250 mg, 4 times a day for 10 days, as a treatment for early Lyme disease should be reconsidered.

The spirochetal etiology of Lyme disease.

TLDR
It is concluded that the I. dammini spirochete is the causative agent of Lyme disease and nymphal or adult lxodes dammini ticks in Connecticut.

In vitro and in vivo susceptibility of the Lyme disease spirochete, Borrelia burgdorferi, to four antimicrobial agents

The antimicrobial susceptibility of Borrelia burgdorferi isolated from human spinal fluid was determined in vitro and in vivo. A broth dilution technique was used to determine the MBCs of four

Lyme disease: A tick-borne spirochetosis

TLDR
A treponema-like spirochete was detected in and isolated from adult Ixodes dammini, the incriminated tick vector of Lyme disease, and it is suggested that the newly discovered spiroChete is involved in the etiology of Lyme Disease.

Lyme disease is a spirochetosis: A review of the disease and evidence for its cause

TLDR
Fourteen patients with Lyme disease showed typical clinical features of erythema chronicum migrans and spirochetes were subsequently cultured from a typical skin lesion and corroborate previous indirect evidence that a spiroChete might be the cause of Lyme disease.

Spirochetes isolated from the blood of two patients with Lyme disease.

We isolated spirochetes from the blood of 2 of 36 patients in Long Island and Westchester County, New York, who had signs and symptoms suggestive of Lyme disease. The spirochetes were morphologically

The early clinical manifestations of Lyme disease.

TLDR
Patients with Lyme disease sometimes had evidence of meningeal irritation, mild encephalopathy, migratory musculoskeletal pain, hepatitis, generalized lymphadenopathy and splenomegaly, sore throat, nonproductive cough, or testicular swelling, and signs and symptoms were typically intermittent and changing during a period of several weeks.