Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean children.

@article{Casellas2005AmoxicillinsulbactamVA,
  title={Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean children.},
  author={Javier Mar{\'i}a Casellas and V{\'i}ctor Israele and Marcelo T. Marin and Mar{\'i}a T Ishida and Ricardo M. Heguil{\'e}n and Jorge L. Soutric and H{\'e}ctor J Arenoso and Andr{\'e}s D Sibbald and Daniel Stamboulian},
  journal={International journal of pediatric otorhinolaryngology},
  year={2005},
  volume={69 9},
  pages={1225-33}
}
Streptococcus pneumoniae (Sp) and Haemophilus influenzae (Hi) are the leading bacterial cause of acute otitis media (AOM), having the nasopharynx (NP) as their reservoir. In October 2001 we began a prospective, multicenter, randomized, evaluator blind study, comparing the efficacy of amoxicillin-sulbactam (Ax/S) and amoxicillin-clavulanic acid (Ax/C) for the treatment of non-recurrent AOM (nr-AOM). Both antimicrobial susceptibility (AS) to Ax/S and Ax/C from Sp and Hi carried by study children… CONTINUE READING