Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes.

@article{Muller2008AmoxicillinPI,
  title={Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes.},
  author={Anouk Edwina Muller and Joost Dejongh and Paul M. Oostvogel and Rob A. Voskuyl and Patricia D{\"o}rr and Meindert Danhof and Johan W Mouton},
  journal={American journal of obstetrics and gynecology},
  year={2008},
  volume={198 1},
  pages={
          108.e1-6
        }
}
OBJECTIVE This study was undertaken to study the pharmacokinetics of intravenously administered amoxicillin in pregnant women with preterm premature rupture of the membranes (PPROM). STUDY DESIGN Healthy women with PPROM were recruited and treated with amoxicillin (2 g initially and 1 g subsequently). Blood samples were obtained from the opposite arm and concentrations determined with the use of high-pressure liquid chromatography. Nonlinear mixed-effects modeling was performed in nonlinear… CONTINUE READING
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