Amoxicillin duration and dose for community-acquired pneumonia in children: the CAP-IT factorial non-inferiority RCT.

@article{Barratt2021AmoxicillinDA,
  title={Amoxicillin duration and dose for community-acquired pneumonia in children: the CAP-IT factorial non-inferiority RCT.},
  author={Sam Barratt and Julia A. Bielicki and David Dunn and Saul N. Faust and Adam Finn and Lynda Harper and Pauline Jackson and Mark David Lyttle and Colin V. E. Powell and Louise Rogers and Damian Roland and Wolfgang St{\"o}hr and Kate Sturgeon and Elizabeth J. Vitale and Mandy Wan and Diana M. Gibb and Mike Sharland},
  journal={Health technology assessment},
  year={2021},
  volume={25 60},
  pages={
          1-72
        }
}
BACKGROUND Data are limited regarding the optimal dose and duration of amoxicillin treatment for community-acquired pneumonia in children. OBJECTIVES To determine the efficacy, safety and impact on antimicrobial resistance of shorter (3-day) and longer (7-day) treatment with amoxicillin at both a lower and a higher dose at hospital discharge in children with uncomplicated community-acquired pneumonia. DESIGN A multicentre randomised double-blind 2 × 2 factorial non-inferiority trial in… 

Treatment of the most common respiratory infections in children

The use of antibiotics and corticosteroids is indicated in selected cases with a severe clinical picture and the choice of antibiotic depends on the clinical condition, presumed causative agent, and local epidemiologic circumstances.

Amoxicillin for childhood pneumonia: 3 days versus 7 days

  • Medicine
    Drug and Therapeutics Bulletin
  • 2022
Amoxicillin duration and dose for community acquired pneumonia in children: the CAP-IT factorial non-inferiority RCT.

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Patients- or parent-reported outcomes represent an option for appropriate, defined clinical trial outcomes for pediatric CAP, because the disease in children has a relatively short and potentially self-resolving clinical course.
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