Amoxicillin and clavulanic acid concentrations in gingival crevicular fluid.

@article{Tenenbaum1997AmoxicillinAC,
  title={Amoxicillin and clavulanic acid concentrations in gingival crevicular fluid.},
  author={H Tenenbaum and François Jehl and C Gallion and Marcel Dahan},
  journal={Journal of clinical periodontology},
  year={1997},
  volume={24 11},
  pages={804-7}
}
The beta-lactams are bactericidal antibiotics, but some of them may be inactivated by bacterial beta-lactamases which destroy the beta-lactam ring. The inactivation of amoxicillin by beta-lactamases of gram negative anaerobic bacteria can be circumvented by the addition of clavulanic acid, a beta-lactamases inhibitor. Thus, most of these bacteria are susceptible to this combination. The aim of this study was to investigate the concentrations of amoxicillin and clavulanic acid in gingival… CONTINUE READING

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