Anti-giardia Activity of Hexane Extract of Citrus Aurantifolia (christim) Swingle and Some of Its Constituents
- Irma Guadalupe Domínguez-Vigil, Antonio Heredia-Rojas, David Mata-Cárdenas
The crude ethanol extract from the leaves of Zanthoxylum liebmannianum exhibited inhibitory effect on the reproduction of trophozoites of Entamoeba histolytica (IC(50)=3.48 microg/ml) and Giardia lamblia (IC(50)=58.00 microg/ml). From this extract, asarinin, hyperin, beta-sitosterol, and beta-sitosterol glucoside were isolated. Among them, asarinin was the most active with IC(50) values of 19.86 microg/ml for E. histolytica and 35.45 microg/ml for G. lamblia. The remaining compounds showed moderate activity against both parasites.