Amoeba host-Legionella synchronization of amino acid auxotrophy and its role in bacterial adaptation and pathogenic evolution.

@article{Price2014AmoebaHS,
  title={Amoeba host-Legionella synchronization of amino acid auxotrophy and its role in bacterial adaptation and pathogenic evolution.},
  author={Christopher T. D. Price and Ashley M. Richards and Juanita E. Von Dwingelo and Hala A Samara and Yousef Abu Kwaik},
  journal={Environmental microbiology},
  year={2014},
  volume={16 2},
  pages={350-8}
}
Legionella pneumophila, the causative agent of Legionnaires' disease, invades and proliferates within a diverse range of free-living amoeba in the environment, but upon transmission to humans, the bacteria hijack alveolar macrophages. Intracellular proliferation of L. pneumophila in two evolutionarily distant hosts is facilitated by bacterial exploitation of conserved host processes that are targeted by bacterial protein effectors injected into the host cell. A key aspect of microbe-host… CONTINUE READING