• Corpus ID: 18964430

Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine

@article{Heidari2014AmodiaquineinducedTI,
  title={Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine},
  author={Reza Heidari and Hossein Babaei and Mohammad Ali Eghbal},
  journal={Research in Pharmaceutical Sciences},
  year={2014},
  volume={9},
  pages={97 - 105}
}
Amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. We evaluated amodiaquine-induced toxicity in isolated rat hepatocytes as an in vitro model for studying drug-induced hepatotoxicity. This study attempts to investigate the protective effects of taurine and N-acetyl cysteine against the cytotoxicity induced by amodiaquine. Hepatocytes were prepared by the… 
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