Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism

@article{Zani2013AmnioticFS,
  title={Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism},
  author={A. Zani and Mara Cananzi and F. Fascetti-Leon and G. Lauriti and V. Smith and S. Bollini and M. Ghionzoli and A. D’Arrigo and M. Pozzobon and M. Piccoli and A. Hicks and J. Wells and B. Siow and N. Sebire and C. Bishop and A. Le{\'o}n and A. Atala and M. Lythgoe and A. Pierro and S. Eaton and P. De Coppi},
  journal={Gut},
  year={2013},
  volume={63},
  pages={300 - 309}
}
  • A. Zani, Mara Cananzi, +18 authors P. De Coppi
  • Published 2013
  • Medicine
  • Gut
  • Objective Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity and mortality in neonates and alternative strategies are needed. Stem cells have become a therapeutic option for other intestinal diseases, which share some features with NEC. We tested the hypothesis that amniotic fluid stem (AFS) cells exerted a beneficial effect in a neonatal rat model of NEC. Design Rats intraperitoneally injected with AFS cells and their controls (bone marrow mesenchymal stem cells… CONTINUE READING
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