Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.

@article{Flood1991AmnesticEI,
  title={Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.},
  author={James Flood and J Eileen Morley and E. M. Nemoto e. Owman J. L. Reid K. A. Reimer W. C. Roberts},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 8},
  pages={3363-6}
}
Immediate post-training intracerebroventricular administration of a synthetic peptide homologous to beta protein of brain amyloid, [Gln11]beta-(1-28), caused amnesia for footshock active avoidance training in mice in a dose-dependent fashion. This effect was specific to memory processing since the peptide did not cause amnesia when injected 24 hr after training nor did it disturb storage or retrieval of older memories. Shorter fragments of the amyloid beta protein consisting of residues 12-28… CONTINUE READING

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