Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop.

@article{Sredni2004AmmoniumT,
  title={Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop.},
  author={Benjamin Sredni and Merav Weil and Gennadi A. Khomenok and Ilana Lebenthal and S Teitz and Yael Mardor and Zvi Ram and Arie Orenstein and Amir Kershenovich and Shalom Michowiz and Yan I Cohen and Zvi Harry Rappaport and Ilya Freidkin and Michael Albeck and Dan L. Longo and Yona Kalechman},
  journal={Cancer research},
  year={2004},
  volume={64 5},
  pages={
          1843-52
        }
}
Cancer cells of different solid and hematopoietic tumors express growth factors in respective stages of tumor progression, which by autocrine and paracrine effects enable them to grow autonomously. Here we show that the murine B16 melanoma cell line and two human primary cultures of stomach adenocarcinoma and glioblastoma multiforme (GBM) constitutively secrete interleukin (IL)-10 in an autocrine/paracrine manner. This cytokine is essential for tumor cell proliferation because its… CONTINUE READING

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