Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.

@article{Bergeron2003AmmoniumTA,
  title={Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.},
  author={Marc J. Bergeron and Édith Gagnon and Bernadette Wallendorff and Jean Yves Lapointe and Paul Isenring},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={285 1},
  pages={
          F68-78
        }
}
The Na(+)-K(+)-Cl(-) cotransporters (NKCCs), which belong to the cation-Cl(-) cotransporter (CCC) family, are able to translocate NH4(+) across cell membranes. In this study, we have used the oocyte expression system to determine whether the K(+)-Cl(-) cotransporters (KCCs) can also transport NH4(+) and whether they play a role in pH regulation. Our results demonstrate that all of the CCCs examined (NKCC1, NKCC2, KCC1, KCC3, and KCC4) can promote NH4(+) translocation, presumably through binding… 
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