Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae.


Protylonolide is a lactonic precursor of tylosin aglycone, produced by a mutant of Streptomyces fradiae. It originates from n-butyrate, propionate and acetate units. Studies were carried out using a protylonolide-producing mutant on the correlation between protylonolide biosynthesis, regulation by NH4+ and amino acid metabolism. Protylonolide production… (More)


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