Ammonia pulses and metabolic oscillations guide yeast colony development.

  title={Ammonia pulses and metabolic oscillations guide yeast colony development.},
  author={Zdena Palkov{\'a} and Fr{\'e}d{\'e}ric Devaux and Mark{\'e}ta Icicov{\'a} and Lucie Min{\'a}rikov{\'a} and St{\'e}phane Le Crom and Claude Jacq},
  journal={Molecular biology of the cell},
  volume={13 11},
On solid substrate, growing yeast colonies alternately acidify and alkalinize the medium. Using morphological, cytochemical, genetic, and DNA microarray approaches, we characterized six temporal steps in the "acid-to-alkali" colony transition. This transition is connected with the production of volatile ammonia acting as starvation signal between colonies. We present evidence that the three membrane proteins Ato1p, Ato2p, and Ato3p, members of the YaaH family, are involved in ammonia production… CONTINUE READING

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