Ammonia and bicarbonate transport by rat cortical collecting ducts perfused in vitro.

@article{Knepper1985AmmoniaAB,
  title={Ammonia and bicarbonate transport by rat cortical collecting ducts perfused in vitro.},
  author={Mark A. Knepper and David W. Good and Maurice B. Burg},
  journal={The American journal of physiology},
  year={1985},
  volume={249 6 Pt 2},
  pages={F870-7}
}
We measured bicarbonate and ammonia transport by isolated perfused cortical collecting ducts from deoxycorticosterone-treated rats. With no ammonia in the perfusate and bath solutions, the collecting ducts secreted bicarbonate. The bicarbonate secretion was prevented when the rats were given 40 mM NH4Cl to drink. When 4 mM total ammonia was added to the perfusate and bath, the collecting ducts secreted ammonia and the direction of bicarbonate transport reversed toward absorption. Under those… CONTINUE READING
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