Ammocidin, a new apoptosis inducer in ras-dependent cells from Saccharothrix sp. II. Physico-chemical properties and structure elucidation.

@article{Murakami2001AmmocidinAN,
  title={Ammocidin, a new apoptosis inducer in ras-dependent cells from Saccharothrix sp. II. Physico-chemical properties and structure elucidation.},
  author={Ryo Murakami and Taijiro Tomikawa and Kazuo Shin‐ya and Junko Shinozaki and Takayuki Kajiura and Haruo Seto and Yoichi Hayakawa},
  journal={The Journal of antibiotics},
  year={2001},
  volume={54 9},
  pages={
          714-7
        }
}
The structure of ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. AJ9571, was elucidated to be as shown in Fig. 1 by NMR and degradation studies. Ammocidin consists of a 20-membered macrolide ring and three deoxy sugars identified as 6-deoxy-L-glucose, D-digitoxose and D-olivomycose. 
Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571
Ammocidins B, C and D were isolated from the culture broth of Saccharothrix sp. AJ9571, an ammocidin A-producing strain. Their structures were determined by a detailed spectroscopic analysis and by a
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Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity.
A new apoptosis inducer, ammocidin, was isolated from the culture broth of Saccharothrix sp. AJ9571. Ammocidin induced apoptotic cell death in Ras-dependent Ba/F3-V12 cells with an IC50 of 66 ng/ml.
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Nocardiopsis sp. was found to produce a new active compound designated apoptolidin (Fig. 1). In this report, we describe the production, isolation, physico-chemical properties and biological activity
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Die aus α-Lipomycin (2) isolierten Methylglykoside werden als anomere Methyl-2,6-didesoxy- D-ribo-hexopyranoside (3 a, 4a) und -hexofuranoside (5a, 6a) identifiziert. Im Gleichgewicht enthalt das