Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity.

@article{Murakami2001AmmocidinAN,
  title={Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity.},
  author={Ryo Murakami and Taijiro Tomikawa and Kazuo Shin‐ya and Junko Shinozaki and Takayuki Kajiura and Taisei Kinoshita and Atsushi Miyajima and Haruo Seto and Yoichi Hayakawa},
  journal={The Journal of antibiotics},
  year={2001},
  volume={54 9},
  pages={
          710-3
        }
}
A new apoptosis inducer, ammocidin, was isolated from the culture broth of Saccharothrix sp. AJ9571. Ammocidin induced apoptotic cell death in Ras-dependent Ba/F3-V12 cells with an IC50 of 66 ng/ml. No cell death was observed in IL-3-dependent Ba/F3-V12 cells at less than 100 microg/ml of ammocidin. Ammocidin significantly reduced the phosphorylation level of MAPK and S6K that mediate the anti-apoptotic function of Ras. 
10 Citations
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