Amlodipine prevents monocrotaline-induced pulmonary arterial hypertension and prolongs survival in rats independent of blood pressure lowering.

@article{Mawatari2007AmlodipinePM,
  title={Amlodipine prevents monocrotaline-induced pulmonary arterial hypertension and prolongs survival in rats independent of blood pressure lowering.},
  author={Eiichiro Mawatari and Minoru Hongo and Akio Sakai and Fumiko Terasawa and Masafumi Takahashi and Yoshikazu Yazaki and Osamu Kinoshita and Uichi Ikeda},
  journal={Clinical and experimental pharmacology & physiology},
  year={2007},
  volume={34 7},
  pages={
          594-600
        }
}
1. The present study was designed to examine the role of amlodipine in preventing and reversing monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. 2. Rats were injected with MCT (40 mg/kg, s.c.) and randomly given either 6 mg/kg per day of amlodipine in drinking water or placebo for 3 weeks. Any animals treated with MCT that survived for 3 weeks were given either amlodipine or placebo for the next 3 weeks. 3. Blood pressure was not different between the groups… CONTINUE READING
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