Amlodipine increases endothelial nitric oxide release by modulating binding of native eNOS protein complex to caveolin-1.

@article{Sharma2011AmlodipineIE,
  title={Amlodipine increases endothelial nitric oxide release by modulating binding of native eNOS protein complex to caveolin-1.},
  author={Arpeeta Sharma and Andy E. Trane and Carol Yu and Jean-François Jasmin and Pascal Bernatchez},
  journal={European journal of pharmacology},
  year={2011},
  volume={659 2-3},
  pages={206-12}
}
Amongst calcium channel blockers, amlodipine is known to have unique cardioprotective activities likely attributable to its capacity to increase nitric oxide (NO) release from endothelial cells (EC). Because endothelial NO synthase (eNOS), the main source of NO in EC is known to be inhibited by caveolin-1 (Cav-1), the purpose of this study is to investigate the possibility that amlodipine can modulate eNOS interaction with Cav-1. Using cultured EC, we confirm that amlodipine potentiates… CONTINUE READING