Amlodipine Reduces Inflammation despite Promoting Albuminuria in the Streptozotocin-Induced Diabetic Rat

@inproceedings{Flynn2012AmlodipineRI,
  title={Amlodipine Reduces Inflammation despite Promoting Albuminuria in the Streptozotocin-Induced Diabetic Rat},
  author={Elizabeth R. Flynn and David C. Marbury and R. Taylor Sawyer and Jonathan Y-L Lee and Christine Teutsch and Katalin Kauser and Christine Maric-Bilkan},
  booktitle={Nephron extra},
  year={2012}
}
Amlodipine reduces blood pressure; however, its effect in the diabetic kidney irrespective of its blood pressure-lowering effects is unclear. This study examined the effects of amlodipine (0, 5, 10 and 20 mg/kg; D(A0), D(A5), D(A10) and D(A20), respectively) for 12 weeks on renal functional and structural changes in the streptozotocin-induced diabetic rat, a nonhypertensive model of diabetes-associated hyperfiltration. Compared with nondiabetic rats, diabetes (D) was associated with increased… CONTINUE READING

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