Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation

@article{Zhu2014AmlodipineMI,
  title={Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation},
  author={Yanlin Zhu and F. Wang and Q. Li and M. Zhu and A. Du and W. Tang and W. Chen},
  journal={Drug Metabolism and Disposition},
  year={2014},
  volume={42},
  pages={245 - 249}
}
  • Yanlin Zhu, F. Wang, +4 authors W. Chen
  • Published 2014
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of CYP3A5 in amlodipine metabolism in humans based on its pharmacokinetic differences between CYP3A5… CONTINUE READING
    Effects of atorvastatin on pharmacokinetics of amlodipine in rats and its potential mechanism
    1

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 24 REFERENCES
    The metabolism and pharmacokinetics of amlodipine in humans and animals.
    111
    Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine.
    16