Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation

  title={Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation},
  author={Yanlin Zhu and F. Wang and Q. Li and M. Zhu and A. Du and W. Tang and W. Chen},
  journal={Drug Metabolism and Disposition},
  pages={245 - 249}
  • Yanlin Zhu, F. Wang, +4 authors W. Chen
  • Published 2014
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of CYP3A5 in amlodipine metabolism in humans based on its pharmacokinetic differences between CYP3A5… CONTINUE READING
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