Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties.

@article{Zwieten1994AmlodipineAO,
  title={Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties.},
  author={Peter Adriaan van Zwieten},
  journal={Clinical cardiology},
  year={1994},
  volume={17 9 Suppl 3},
  pages={III3-6}
}
Amlodipine, a third-generation dihydropyridine calcium antagonist, has a mode of action and pharmacodynamic profile which are comparable to those of conventional compounds in this series, such as nifedipine. Its physicochemical behavior, however, appears to be somewhat different. A pKa value of 8.7 means that amlodipine is predominantly present in the ionized form at a physiologic pH. It possesses, therefore, a strong affinity for cell membranes. These phenomena apparently contribute to… CONTINUE READING

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