Amlodipine/Atorvastatin

@article{Curran2012AmlodipineAtorvastatin,
  title={Amlodipine/Atorvastatin},
  author={Monique P. Curran},
  journal={Drugs},
  year={2012},
  volume={70},
  pages={191-213}
}
  • M. Curran
  • Published 2012
  • Biology, Medicine
  • Drugs
Amlodipine/atorvastatin (Caduet®) is a single-tablet, fixed-dose combination of the dihydropyridine calcium channel antagonist amlodipine and the HMG-CoA reductase inhibitor atorvastatin. The bioavailability of amlodipine and atorvas-tatin with a single-tablet, fixed-dose amlodipine/atorvastatin combination was not significantly different to that with coadministered separate amlodipine and atorvastatin tablets. In well controlled clinical trials in patients with hypertension and dyslipidaemia… 
8 Citations
Does a fixed-dose combination of amlodipine and atorvastatin improve persistence with therapy in the Australian population?
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A lower risk of ceasing combination therapy is found when people initiate amlodipine and statin in the form of a FDC, which supports findings in other countries that FDCs improve persistence with combination therapy.
A randomized, double‐blind clinical trial to evaluate the efficacy and safety of a fixed‐dose combination of amlodipine/rosuvastatin in patients with dyslipidemia and hypertension
TLDR
In hypertensive patients with dyslipidemia, combination treatment with rosuvastatin 20 mg + amlodipine 10 mg effectively reduced blood pressure and LDL‐C levels while maintaining safety.
Simvastatin and amlodipine induced thrombocytopenia in the same patient: double trouble and a literature review
TLDR
An investigation of the causal relationship of amlodipine and simvastatin with thrombocytopenia occurring in the same patient is reported on, and the literature is reviewed.
Study on Polypharmacy in Patients with Cardiovascular Diseases
TLDR
Careful and thoughtful drug prescription strategy seems to be able to eliminate most of the cases of polypharmacy even in patients who are suffering from a multiplace disorders simultaneously, which provides support for development of new drugs that take into account compatibility with other medication, especially in elderly people.
The value of the polypill in cardiovascular disease: an Italian multidisciplinary Delphi panel consensus
TLDR
Panel members agreed to recognize polypill as effective in reducing cardiovascular events, blood pressure and lipids, cardiovascular risk and the weight of therapy, in therapeutic adherence improvement, in the absence of differences in bioavailability between drugs administered in fixed or free combinations and the better cost-effectiveness profile compared with standard care.

References

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Amlodipine/Atorvastatin Fixed-Dose Combination
  • K. McKeageM. Siddiqui
  • Medicine, Biology
    American journal of cardiovascular drugs : drugs, devices, and other interventions
  • 2008
TLDR
The convenience of single-pill amlodipine/atorvastatin has the potential to improve patient adherence and the management of cardiovascular risk in selected patients, thereby improving clinical outcomes.
Coadministered amlodipine and atorvastatin produces early improvements in arterial wall compliance in hypertensive patients with dyslipidemia.
TLDR
Early and sustained improvement in small artery compliance was observed following coadministration of amlodipine and atorvastatin, thus demonstrating a vascular benefit with simultaneous treatment of hypertension and dyslipidemia.
Bioavailability of Amlodipine Besylate/Atorvastatin Calcium Combination Tablet
TLDR
Use of amlodipine/atorvastatin combination tablets may provide a more integrated approach to treatment of cardiovascular risk and bioequivalence for amlidipine and atorVastatin at both dose strengths is demonstrated.
Treatment with amlodipine and atorvastatin has additive effect on blood and plaque inflammation in hypertensive patients with carotid atherosclerosis.
TLDR
The results suggest that combined treatment with atorvastatin and amlodipine decreases inflammatory status of atherosclerotic patients more than atorVastatin treatment alone, suggesting that co-administration of both drugs could have beneficial additive effects.
Effects of amlodipine-atorvastatin combination on inflammation markers and insulin sensitivity in normocholesterolemic obese hypertensive patients
TLDR
In normocholesterolemic, obese hypertensive patients, the amlodipine-atorvastatin combination decreased inflammatory markers and IR more than amlidipine monotherapy and produced a greater SBP and DBP reduction.
Improved attainment of blood pressure and cholesterol goals using single-pill amlodipine/atorvastatin in African Americans: the CAPABLE trial.
TLDR
Single-pill amlodipine/atorvastatin therapy was well tolerated and effectively targeted HTN and dyslipidemia in this population of African Americans who were at risk of cardiovascular disease.
Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease.
TLDR
Amlodipine provides an attractive therapeutic option for the treatment of hypertension, and offers potential for patients with angina pectoris, and its beneficial effects in patients with congestive heart failure require confirmation in future studies.
Differential Effects of Amlodipine and Atorvastatin Treatment and Their Combination on Atherosclerosis in ApoE*3‐Leiden Transgenic Mice
TLDR
It is demonstrated that amlodipine treatment alone does not significantly reduce atherosclerotic lesion development, and cotreatment with amlidipine may potentiate the antiatherosclerosis effect of atorvastatin.
Synergistic Effect of Amlodipine and Atorvastatin in Reversing LDL-Induced Endothelial Dysfunction
TLDR
Small-angle X-ray diffraction analysis indicates that amlodipine and AT are lipophilic and share an overlapping molecular location in the cell membrane that could facilitate electron transfer for antioxidant mechanisms, and indicates a synergistic effect of AML and AT on an increase in NO concentration, reduction of nitroxidative stress.
Anti-Atherosclerotic Effect of Amlodipine, Alone and in Combination With Atorvastatin, in APOE*3-Leiden/hCRP Transgenic Mice
TLDR
Treatment with amlodipine, independently of blood pressure lowering, reduced atherosclerosis development in E3L/CRP mice and combined treatment with atorvastatin had a strong anti-atherosclerotic effect, whereas co-treatment withAmlodIPine enhanced this effect significantly.
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