Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system.

@article{Botney1983AmitriptylinePM,
  title={Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system.},
  author={Mitchell D Botney and Howard L Fields},
  journal={Annals of neurology},
  year={1983},
  volume={13 2},
  pages={160-4}
}
Trycyclic antidepressants are often effective in the management of neuropathic pains. To elucidate the mechanism of tricyclic-induced analgesia, amitriptyline and other drugs were injected into lightly anesthetized rats either systemically or via lumbar intrathecal cannulas. Analgesia was assessed by measuring the latency of the tail flick reflex. Using this model, intrathecal amitriptyline (30 micrograms) significantly enhanced the analgesic effect of an intraperitoneal dose of morphine (0.5… CONTINUE READING

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