Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers.

  title={Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers.},
  author={Britt Mellstr{\"o}m and Juliette S{\"a}we and Leif Bertilsson and Folke Sj{\"o}qvist},
  journal={Clinical pharmacology and therapeutics},
  volume={39 4},
Eleven healthy nonsmokers with wide variation in the ability to hydroxylate debrisoquin (D) were given single oral doses of amitriptyline and nortriptyline on different occasions. The urinary D/4-hydroxy-D ratio correlated significantly (P less than 0.01) with all three parameters of amitriptyline disposition measured (total plasma clearance, clearance by demethylation, and clearance by pathways other than demethylation), with rs = -0.89, -0.78, and -0.83, respectively. In contrast, we failed… CONTINUE READING

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