Amitriptyline-induced loss of tight junction integrity in a human endothelial--smooth muscle cell bi-layer model.

@article{Dahlin1999AmitriptylineinducedLO,
  title={Amitriptyline-induced loss of tight junction integrity in a human endothelial--smooth muscle cell bi-layer model.},
  author={Kristina Dahlin and K{\"a}th Bohlin and Johan Strindlund and {\AA}ke Ryrfeldt and Ian A. Cotgreave},
  journal={Toxicology},
  year={1999},
  volume={136 1},
  pages={
          1-13
        }
}
Tricyclic antidepressants can, when taken in overdose, cause serious pulmonary failure such as the adult respiratory distress syndrome (ARDS). In this study we have examined the effects of some tricyclic antidepressants (amitriptyline, imipramine, nortriptyline and desipramine) on the viability and morphology of human endothelial and smooth muscle cells derived from umbilical cord. Effects of amitriptyline on endothelial cell fluidity, as well as permeability changes to an endothelial-smooth… CONTINUE READING
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