Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activation

@article{Rathbun2004AmitriptylineAN,
  title={Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activation},
  author={Robert C. Rathbun and Irwin H. Slater},
  journal={Psychopharmacologia},
  year={2004},
  volume={4},
  pages={114-125}
}
Summary1.The anticholinergic activity of amitriptyline and a new antidepressant, nortriptyline, which is a secondary amine related to amitriptyline, were compared on guinea pig ileum and salivation of dogs. Both are active anticholinergic agents, but somewhat atypical, by these tests. Amitriptyline caused suppression of salivation at lower doses than nortriptyline. On guinea pig ileum, amitriptyline was about twice as active as nortriptyline.2.Both compounds decrease the tremor and salivation… 

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