Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats

@article{Tai2009AmitriptylineSN,
  title={Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats},
  author={Y. Tai and R. Tsai and Shinn-Long Lin and C. Yeh and J. Wang and P. Tao and Chih-Shung Wong},
  journal={Anesthesiology},
  year={2009},
  volume={110},
  pages={1379-1389}
}
Background:This study explores the underlying mechanism of the antiinflammatory effect of amitriptyline in chronic morphine-infused rats. Methods:Male Wistar rats were implanted with two intrathecal catheters. One catheter was for the continuous infusion of saline, amitriptyline (15 &mgr;g/h), morphine (15 &mgr;g/h), p38 mitogen-activated protein kinase inhibitor SB203580 (0.5 &mgr;g/h), morphine plus amitriptyline, or morphine plus amitriptyline plus SB203580 for 5 days. The other catheter was… Expand
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References

SHOWING 1-10 OF 68 REFERENCES
Amitriptyline suppresses neuroinflammation and up-regulates glutamate transporters in morphine-tolerant rats
  • 142
Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance
  • 158
Amitriptyline preserves morphine’s antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats
  • 62
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
  • 952
  • Highly Influential
Negative Immunoregulatory Effects of Antidepressants: Inhibition of Interferon-γ and Stimulation of Interleukin-10 Secretion
  • 316
  • PDF
Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Inducible Nitric-oxide Synthase Expression in Mouse Astrocytes*
  • 304
  • PDF
Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells
  • 282
A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine
  • 375
  • Highly Influential
  • PDF
Tricyclic antidepressants inhibit IL-6, IL-1 beta and TNF-alpha release in human blood monocytes and IL-2 and interferon-gamma in T cells.
  • 100
Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice
  • 48
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4
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