Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats

@article{Tai2009AmitriptylineSN,
  title={Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats},
  author={Y. Tai and R. Tsai and Shinn-Long Lin and C. Yeh and J. Wang and P. Tao and Chih-Shung Wong},
  journal={Anesthesiology},
  year={2009},
  volume={110},
  pages={1379-1389}
}
Background:This study explores the underlying mechanism of the antiinflammatory effect of amitriptyline in chronic morphine-infused rats. Methods:Male Wistar rats were implanted with two intrathecal catheters. One catheter was for the continuous infusion of saline, amitriptyline (15 &mgr;g/h), morphine (15 &mgr;g/h), p38 mitogen-activated protein kinase inhibitor SB203580 (0.5 &mgr;g/h), morphine plus amitriptyline, or morphine plus amitriptyline plus SB203580 for 5 days. The other catheter was… Expand
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References

SHOWING 1-10 OF 68 REFERENCES
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
  • 952
  • Highly Influential
Negative Immunoregulatory Effects of Antidepressants: Inhibition of Interferon-γ and Stimulation of Interleukin-10 Secretion
  • 316
  • PDF
A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine
  • 375
  • Highly Influential
  • PDF
...
1
2
3
4
5
...