Amitriptyline Is a Potent Blocker of Human Kv1.1 and Kv7.2/7.3 Channels

@article{Punke2007AmitriptylineIA,
  title={Amitriptyline Is a Potent Blocker of Human Kv1.1 and Kv7.2/7.3 Channels},
  author={M. A. Punke and P. Friederich},
  journal={Anesthesia & Analgesia},
  year={2007},
  volume={104},
  pages={1256-1264}
}
  • M. A. Punke, P. Friederich
  • Published 2007
  • Medicine
  • Anesthesia & Analgesia
  • BACKGROUND: Kv1.1 and Kv7.2/7.3 channels control excitability of neuronal cells. As hyperexcitability is a sign of neuropathic pain, epilepsy, and anxiety disorders, these channels may be important molecular targets of amitriptyline that cause pharmacological as well as toxicological effects by altering neuronal excitability. Since the molecular mechanisms underlying these effects of amitriptyline have not been fully elucidated, we aimed to characterize the interaction of amitriptyline with… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 40 REFERENCES
    Involvement of potassium channels in amitriptyline and clomipramine analgesia
    52
    Retigabine Stimulates Human KCNQ2/Q3 Channels in the Presence of Bupivacaine
    9