Amitriptyline Is a Potent Blocker of Human Kv1.1 and Kv7.2/7.3 Channels

@article{Punke2007AmitriptylineIA,
  title={Amitriptyline Is a Potent Blocker of Human Kv1.1 and Kv7.2/7.3 Channels},
  author={Mark Andree Punke and Patrick Friederich},
  journal={Anesthesia \& Analgesia},
  year={2007},
  volume={104},
  pages={1256-1264}
}
BACKGROUND: Kv1.1 and Kv7.2/7.3 channels control excitability of neuronal cells. As hyperexcitability is a sign of neuropathic pain, epilepsy, and anxiety disorders, these channels may be important molecular targets of amitriptyline that cause pharmacological as well as toxicological effects by altering neuronal excitability. Since the molecular mechanisms underlying these effects of amitriptyline have not been fully elucidated, we aimed to characterize the interaction of amitriptyline with… 

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  • Medicine, Biology
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 2018
TLDR
Amitriptyline effectively reduces the activity of cold thermoreceptors, although its efficacy is different in intact and tear-deficient corneas, which might be due to the changes induced by ocular dryness in the expression of the various voltage-gated Na+ channels responsible of the action potential generation and propagation.
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