Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology – a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist

@article{Wetzel1998AmisulprideVF,
  title={Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology – a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist},
  author={Hermann Wetzel and Gerhard Gr{\"u}nder and Andreas Hillert and Michael Philipp and Wagner F. Gattaz and Heinrich Sauer and Guido Adler and Joachim Schr{\"o}der and Werner Rein and Otto Benkert},
  journal={Psychopharmacology},
  year={1998},
  volume={137},
  pages={223-232}
}
The benzamide amisulpride (ASP) is a selective D2-like dopamine antagonist, while flupentixol (FPX), a thioxanthene, blocks D2-like, D1-like and 5-HT2 receptors. To evaluate efficacy and safety of ASP and to investigate the importance of an additional D1-like antagonism for antipsychotic effects and extrapyramidal tolerability, a randomized double-blind multi-center study versus FPX as reference drug was performed for 6 weeks in 132 patients suffering from acute schizophrenia (DSM-III-R) with… CONTINUE READING

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View 13 Excerpts
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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

P Sokolo, B Giros, MP Martres, ML Bouthenet, JC Schwartz
Nature • 1990
View 4 Excerpts
Highly Influenced

A rating scale for drug-induced akathisia.

The British journal of psychiatry : the journal of mental science • 1989
View 7 Excerpts
Highly Influenced

E¤ect of chronic treatment

L Hansen
1993
View 7 Excerpts
Highly Influenced

Etude multicentrique controlée en double insu. Amisulpride (Solian 200) versus halopéridol à forte dose dans les états psychotiques aigus

P Pichot, P Boyer
Ann Psychiatr • 1988
View 4 Excerpts
Highly Influenced

Clinical trials. A practical approach

SJ Pocock
1983
View 2 Excerpts
Highly Influenced

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