Amisulpride the ‘atypical’ atypical antipsychotic — Comparison to haloperidol, risperidone and clozapine

@article{Natesan2008AmisulprideT,
  title={Amisulpride the ‘atypical’ atypical antipsychotic — Comparison to haloperidol, risperidone and clozapine},
  author={Sridhar Natesan and Greg E. Reckless and Karren B. L. Barlow and Jos{\'e} N. Nobrega and Shitij Kapur},
  journal={Schizophrenia Research},
  year={2008},
  volume={105},
  pages={224-235}
}
INTRODUCTION Amisulpride's high and selective affinity for dopamine D2/3 (Ki 1.3/2.4 nM) receptors, lack of affinity for serotonin receptors, and its unusually high therapeutic doses (400-800 mg/day) makes it unique among atypical antipsychotics and prompted us to compare its actions with other antipsychotics in animal models. METHODS Amisulpride's effects on amphetamine and phencyclidine induced locomotor activity (AIL/PIL), conditioned avoidance response, catalepsy (CAT), subcortical Fos… Expand
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This report is unique in the sense that clozapine in this treatment-resistant case of schizophrenia was totally replaced by amisulpride. Expand
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