Amisulpride plus valproate vs haloperidol plus valproate in the treatment of acute mania of bipolar I patients: a multicenter, open-label, randomized, comparative trial

@article{Thomas2008AmisulpridePV,
  title={Amisulpride plus valproate vs haloperidol plus valproate in the treatment of acute mania of bipolar I patients: a multicenter, open-label, randomized, comparative trial},
  author={Pierre Thomas and Eduard Vieta},
  journal={Neuropsychiatric Disease and Treatment},
  year={2008},
  volume={4},
  pages={675 - 686}
}
The primary objective of this study was to compare the effectiveness of combination treatment of valproate and amisulpride with that of valproate and haloperidol in bipolar I disorder. Adult inpatients with a current manic episode fulfilling DSM-IV-TR diagnostic criteria for bipolar type I disorder were included. Patients were randomized to amisulpride (400-800 mg/day) or haloperidol (5-15 mg/day) for 3 months and all received valproate. The primary effectiveness criterion was the percentage of… CONTINUE READING
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Note for guidance on clinical investigation of medical products in the treatment and prevention of bipolar disorder

  • GM Goodwin
  • 2007

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