Amiodarone-mediated increase in intracellular free Ca2+ associated with cellular injury to human pulmonary artery endothelial cells.

@article{Powis1990AmiodaronemediatedII,
  title={Amiodarone-mediated increase in intracellular free Ca2+ associated with cellular injury to human pulmonary artery endothelial cells.},
  author={Garth Powis and Randi Grung Olsen and Joseph E. Standing and Diane L. Kachel and W J Martin},
  journal={Toxicology and applied pharmacology},
  year={1990},
  volume={103 1},
  pages={
          156-64
        }
}
  • Garth Powis, Randi Grung Olsen, +2 authors W J Martin
  • Published in
    Toxicology and applied…
    1990
  • Chemistry, Medicine
  • The cardiac antidysrrhythmic drug amiodarone can give rise to potentially fatal pulmonary toxicity in large numbers of patients. The effect of amiodarone on Ca2+ homeostasis and cell injury has been studied using human pulmonary artery endothelial (HPAE) cells in vitro. Amiodarone produced a concentration-dependent increase in intracellular free Ca2+ concentration ( [Ca2+]i) to micromolar levels that are similar to those seen with physiological stimuli that increase [Ca2+]i. Unlike… CONTINUE READING

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