Amiodarone induced lipidosis similar to Niemann-Pick C disease. Biochemical and morphological study.

@article{Palmeri1995AmiodaroneIL,
  title={Amiodarone induced lipidosis similar to Niemann-Pick C disease. Biochemical and morphological study.},
  author={Silvia Palmeri and Cesare Battisti and Alessandro Malandrini and Antonio Federico},
  journal={Life sciences},
  year={1995},
  volume={57 21},
  pages={1963-71}
}
Amiodarone is effective in the treatment of supraventricular and ventricular cardiac arrhythmia, however a high incidence of toxic side effects has been observed in various organs and tissues during chronic treatment. Ultrastructural observation of affected tissues reveals myelinoid inclusion bodies. The exact pathogenetic mechanism of these changes is still unknown. In this study we investigated the biochemical effects of this drug on lysosomal hydrolases and the alterations induced in… CONTINUE READING