Amiodarone improves cardiac sympathetic nerve function to hold norepinephrine in the heart, prevents left ventricular remodeling, and improves cardiac function in rat dilated cardiomyopathy.

@article{Tachikawa2005AmiodaroneIC,
  title={Amiodarone improves cardiac sympathetic nerve function to hold norepinephrine in the heart, prevents left ventricular remodeling, and improves cardiac function in rat dilated cardiomyopathy.},
  author={Hitoshi Tachikawa and Makoto Kodama and Kenichi Watanabe and Toshihiro Takahashi and Meilei Ma and Takeshi Kashimura and Masahiro Ito and Satoru Hirono and Yuji Okura and Kiminori Kato and Haruo Hanawa and Yoshifusa Aizawa},
  journal={Circulation},
  year={2005},
  volume={111 7},
  pages={894-9}
}
BACKGROUND It is unclear how amiodarone therapy exerts its effects on left ventricular remodeling and cardiac sympathetic nerve function in chronic heart failure. We investigated long-term effects of amiodarone on rat dilated cardiomyopathy after healing of cardiac myosin-induced autoimmune myocarditis. METHODS AND RESULTS Rats were treated with oral amiodarone or vehicle for 6 weeks. We determined cardiac function, left ventricular remodeling, and cardiac sympathetic nerve function with… CONTINUE READING

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