Amiodarone fails to improve survival in amitriptyline-poisoned mice.

  title={Amiodarone fails to improve survival in amitriptyline-poisoned mice.},
  author={Fermin F Barrueto and Amy Chuang and Brian W. Cotter and Robert S Hoffman and Lewis S Nelson},
  journal={Clinical toxicology},
  volume={43 3},
OBJECTIVE Amiodarone, a class III antidysrhythmic agent, blocks Na+, Ca2+, and K+ channels as well as the beta-adrenergic receptor. Despite increased use of amiodarone for wide-complex tachycardia, its efficacy in the treatment of dysrhythmias induced by tricyclic antidepressants has not been tested. We investigated the effect of amiodarone and amitriptyline in a mouse lethality model. METHODS The LD50 of amitriptyline obtained from reference sources was confirmed by giving 100 mg/kg to 40… CONTINUE READING